Symptoms
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Cannot open PHP Info page atDomains > example.com > PHP Settings > View the phpinfo() page: Server Error 
 500
 PleskUtilException
 Access denied
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Unable to install Let's Encrypt certificate for a domain in Plesk with error below: Status: 403 
 Detail: The key authorization file from the server did not match this challenge
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Website may be inaccessible with: 500 external server error 
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One of the errors below can be observed with Plesk File Manager: - 
Cannot change file permissions at Domains > example.com > File Manager: filemng failed: Unable to get the object (C:Inetpubvhostsexample.comhttpdocspathfile) security info: (5) Access is denied. 
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Unable to access file or directory in File Manager with the following error: Unable to open the directory: Unable to find the directory C:Inetpubvhostsexample.comhttpdocs: Access denied 
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Unable to create zip archive in File Manager: Unable to create the archive: 7-Zip [32] 16.04 
 %plesk_vhosts%example.comhttpdocsarchive.zip
 Items to compress: 14161 WARNING: Access is denied
 WARNING: Cannot open 13 files at (CreateZip::onRunAsUser line 2783).
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Unable to rename/create file(or directory)/access domain's document root in File Manager with the following error: Unable to find the directory C:Inetpubvhostsexample.com: Access denied 
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'Change Permissions' option in File Manager shows all the boxes are unmarked for the subscription system user, the permissions get automatically reset 
 
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Cause
The system user does not have permissions to access subscription directories or incorrect security settings in %plesk_vhosts%example.com.plesk.Security file.
Resolution
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Connect to the server using RDP. Note: if direct RDP access to the server is not possible, contact server administrator for further assistance. 
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Rename the .Securityfile to.Security.bakin%plesk_vhosts%example.com.pleskdirectory.
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Open Command Prompt as Administrator and execute the following command: C:> "%plesk_cli%repair.exe" --repair-webspace-security -webspace-name example.com -all-filesystem-objects 
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If there is %plesk_dir%etcDiskSecuritypermissions.xmlfile for customizing permissions, review the file and remove the folders of the domain in question